You can disable to an extent, but you'll still be using the Sense launcher or Rosie. I don't know why you'd want to disable Sense if the hardware can handle it, the widgets for Sense are better than stock Android (you can scroll in Sense widgets.)
I'm more of a simplistic person i don't use hardly any widgets i feel they are constantly active so they burn up battery. Only widget i use on my nexus is the search, power, and weather. If i need to go to messages or something, i just launch the app, albeit Sense UI do have nice widgets. Even though i enjoy some of the 3d games like the baseball i hardly play them, i played sonic and all that stuff wayyyy more.
You can disable to an extent, but you'll still be using the Sense launcher or Rosie. I don't know why you'd want to disable Sense if the hardware can handle it, the widgets for Sense are better than stock Android (you can scroll in Sense widgets.)